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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732147
Species: Homo sapiens
RGD Object: Gene
Symbol: MTHFD1
Name: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Acc ID: CHEBI:3908
Term: coumestrol
Definition: A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.
Chemical ID: MESH:D003375
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTHFD1increases expressionEXP 6480464CTDCoumestrol results in increased expression of MTHFD1 mRNAPMID:19167446
MTHFD1multiple interactionsEXP 6480464CTD[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MTHFD1 mRNA; [Coumestrol co-treated with Resveratrol] results in increased expression of MTHFD1 mRNAPMID:19167446
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