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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:3908
Term: coumestrol
Definition: A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.
Chemical ID: MESH:D003375
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDCoumestrol binds to ESR2 protein

PMID:19913605
affects response to substanceEXP 6480464CTDESR2 protein affects the susceptibility to Coumestrol

PMID:23526725
increases expressionEXP 6480464CTDCoumestrol results in increased expression of ESR2 protein, Coumestrol results in increased expression of ESR2 protein alternative form

PMID:21708076, PMID:27634370
multiple interactionsEXP 6480464CTDESR2 protein affects the reaction [Coumestrol results in increased expression of SOD2 protein]

PMID:23526725
affects bindingISORGD:25826480464CTDCoumestrol binds to ESR2 protein

PMID:19913605
affects bindingISORGD:692136480464CTDCoumestrol binds to ESR2 protein

PMID:11518614, PMID:12224631, PMID:16566672, PMID:19913605
affects response to substanceISORGD:692136480464CTDESR2 protein affects the susceptibility to Coumestrol

PMID:17275032
increases activityISORGD:692136480464CTDCoumestrol results in increased activity of ESR2 protein

PMID:16118406
multiple interactionsISORGD:25826480464CTDCoumestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein], Coumestrol inhibits the reaction [Estradiol binds to ESR2 protein alternative form]

PMID:9048584, PMID:9492041
multiple interactionsISORGD:692136480464CTDCoumestrol binds to and results in increased activity of ESR2 protein, Coumestrol inhibits the reaction [Estradiol binds to ESR2 protein], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ADRA2A mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ANLN mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ANP32E mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ASPM mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of AURKA mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of BIN3 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CCNA2 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CDCA3 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CENPF mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CLCC1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CTNNAL1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CXCL12 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of DEPDC1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of DEPDC1B mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of DHRS2 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of EXOSC9 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of FABP5 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of FCMR mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of FHL1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of GAL mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of GPSM2 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of GREB1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of GTSE1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of HMGB2 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of HMMR mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IGFBP4 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IL17RB mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IL20 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KCNK5 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KIF18A mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of MKI67 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of MYB mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of MYC mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of NCAPG mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of NEK2 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of NPY1R mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of NUSAP1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PDLIM3 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PDZK1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PIF1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PKIB mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PLK1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of RACGAP1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of RERG mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of SLC26A2 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of SPC25 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ST8SIA6 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of STC2 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of TFF1 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA], ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of TRAF4 mRNA], ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CDKN2C mRNA], ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CDKN3 mRNA], ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KIF14 mRNA], ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KIF15 mRNA], ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KIF20A mRNA], ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of TOP2A mRNA]

PMID:12765243, PMID:15084758, PMID:16566672, PMID:18310284, PMID:9751507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.