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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1298347
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP7
Name: caspase 7
Acc ID: CHEBI:38940
Term: sunitinib
Definition: A pyrrole that has formula C22H27FN4O2.
Chemical ID: MESH:C473478
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP7increases cleavageEXP 6480464CTDsunitinib results in increased cleavage of CASP7 proteinPMID:21906609
CASP7increases expressionEXP 6480464CTDSunitinib results in increased expression of CASP7 mRNAPMID:31533062
CASP7multiple interactionsEXP 6480464CTDAICA ribonucleotide inhibits the reaction [sunitinib results in increased cleavage of CASP7 protein]; Metformin inhibits the reaction [sunitinib results in increased cleavage of CASP7 protein]PMID:21906609
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