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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:38912
Term: Ro 31-8220
Definition: An imidothiocarbamic ester that has formula C25H23N5O2S.
Chemical ID: MESH:C064758
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junmultiple interactionsEXP 6480464CTDRo 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein], Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]

PMID:12169099, PMID:19002563
Jundecreases expressionISORGD:108286480464CTDRo 31-8220 results in decreased expression of JUN mRNA

PMID:11353138
Junmultiple interactionsISORGD:108286480464CTDRo 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA], Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]

PMID:11353138, PMID:11568973
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.