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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:38912
Term: Ro 31-8220
Definition: An imidothiocarbamic ester that has formula C25H23N5O2S.
Chemical ID: MESH:C064758
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsISORGD:7309816480464CTDRo 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA], Ro 31-8220 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone], Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

PMID:10712238, PMID:11854442, PMID:18054255
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.