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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:38912
Term: Ro 31-8220
Definition: An imidothiocarbamic ester that has formula C25H23N5O2S.
Chemical ID: MESH:C064758
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1multiple interactionsISORGD:7309016480464CTDRo 31-8220 inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA], Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein], Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]

PMID:18048804, PMID:18357586, PMID:26275128
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.