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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10765
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:38757
Term: isoflavones
Definition: Any isoflavonoid with a 3-aryl-1-benzopyran-4-one (3-aryl-4H-chromen-4-one) skeleton and its substituted derivatives.
Chemical ID: MESH:D007529
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1multiple interactionsEXP 6480464CTDIsoflavones promotes the reaction [Capsaicin results in increased expression of IGF1 protein]PMID:17569567
Igf1affects expressionISOIgf1 (Rattus norvegicus)6480464CTDIsoflavones affects the expression of IGF1 mRNAPMID:18522411
Igf1multiple interactionsISOIgf1 (Rattus norvegicus)6480464CTDIsoflavones inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of IGF1 mRNA]; Isoflavones inhibits the reaction [Diethylhexyl Phthalate results in increased methylation of IGF1 promoter]PMID:34197824
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTD[Capsaicin co-treated with Isoflavones] results in increased expression of IGF1 proteinPMID:19502719
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