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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:38757
Term: isoflavones
Definition: Any isoflavonoid with a 3-aryl-1-benzopyran-4-one (3-aryl-4H-chromen-4-one) skeleton and its substituted derivatives.
Chemical ID: MESH:D007529
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects expressionISOEsr2 (Rattus norvegicus)6480464CTDIsoflavones affects the expression of ESR2PMID:21112483
Esr2affects response to substanceISOESR2 (Homo sapiens)6480464CTDESR2 gene SNP affects the susceptibility to IsoflavonesPMID:16522905
Esr2decreases expressionISOEsr2 (Rattus norvegicus)6480464CTDIsoflavones results in decreased expression of ESR2 proteinPMID:22155228
Esr2multiple interactionsISOEsr2 (Rattus norvegicus)6480464CTD[Genistein co-treated with Isoflavones] results in increased expression of ESR2 mRNAPMID:20381596
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