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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10127
Species: Mus musculus
RGD Object: Gene
Symbol: Ahr
Name: aryl-hydrocarbon receptor
Acc ID: CHEBI:38757
Term: isoflavones
Definition: Any isoflavonoid with a 3-aryl-1-benzopyran-4-one (3-aryl-4H-chromen-4-one) skeleton and its substituted derivatives.
Chemical ID: MESH:D007529
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahrincreases activityEXP 6480464CTDIsoflavones analog results in increased activity of AHR proteinPMID:22507882
Ahrmultiple interactionsEXP 6480464CTDAHR protein affects the reaction [Isoflavones analog results in increased expression of CYP1B1 mRNA]PMID:31621310
Ahrincreases activityISOAHR (Homo sapiens)6480464CTDIsoflavones analog results in increased activity of AHR proteinPMID:22507882
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTDAHR protein affects the reaction [Isoflavones analog results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Isoflavones analog results in increased expression of UGT1A1 mRNA]; Isoflavones analog inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]PMID:22507882 PMID:31621310
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