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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:38746
Term: parathion-methyl
Definition: A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D008743
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bchedecreases activityEXP 6480464CTDMethyl Parathion results in decreased activity of BCHE proteinPMID:11405414 PMID:11481665
Bchemultiple interactionsEXP 6480464CTD[Methyl Parathion co-treated with Chlorpyrifos] results in decreased activity of BCHE protein; [Methyl Parathion co-treated with Diazinon] results in decreased activity of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE proteinPMID:11405414 PMID:11481665 PMID:17963125
Bchemultiple interactionsISOBCHE (Homo sapiens)6480464CTD[Methyl Parathion co-treated with Parathion] results in decreased activity of BCHE proteinPMID:1512808
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