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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:38746
Term: parathion-methyl
Definition: A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D008743
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDMethyl Parathion results in increased expression of CYP1A1 mRNAPMID:19800895
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTDMethyl Parathion inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]PMID:19800895
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