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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315695
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1C1
Name: aldo-keto reductase family 1 member C1
Acc ID: CHEBI:38746
Term: parathion-methyl
Definition: A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D008743
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1C1increases activityEXP 6480464CTDMethyl Parathion results in increased activity of AKR1C1 proteinPMID:19800895
AKR1C1increases expressionEXP 6480464CTDMethyl Parathion results in increased expression of AKR1C1 mRNAPMID:19800895
AKR1C1multiple interactionsEXP 6480464CTDAKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]; Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C1 protein]; Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C1 mRNA]PMID:19800895
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