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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735878
Species: Homo sapiens
RGD Object: Gene
Symbol: ACHE
Name: acetylcholinesterase (Yt blood group)
Acc ID: CHEBI:38730
Term: omethoate
Definition: An organothiophosphate insecticide that has formula C5H12NO4PS.
Chemical ID: MESH:C002302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACHEdecreases activityEXP 6480464CTDdimethoxon metabolite results in decreased activity of ACHE protein; dimethoxon results in decreased activity of ACHE proteinPMID:18070496 PMID:30625376 PMID:8783813
ACHEmultiple interactionsEXP 6480464CTDasoxime chloride inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]PMID:8783813
ACHEdecreases activityISOAche (Rattus norvegicus)6480464CTDdimethoxon results in decreased activity of ACHE proteinPMID:11985885 PMID:15793557
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