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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:38683
Term: 4-nitro-m-cresol
Definition: A C-nitro compound in which the nitro group is attached at C-4 of m-cresol.
Chemical ID: MESH:C008636
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityEXP 6480464CTD4-nitro-3-cresol results in increased activity of CASP3 proteinPMID:22467373 PMID:29307546
Casp3multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [4-nitro-3-cresol results in increased activity of CASP3 protein]PMID:22467373
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTD4-nitro-3-cresol results in increased activity of CASP3 proteinPMID:29307546
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDCASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FAS protein]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG mRNA]; CASP3 protein promotes the reaction [4-nitro-3-cresol results in increased expression of FASLG protein]PMID:29307546
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