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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:38663
Term: ethion
Definition: An organic thiophosphate that is S,S'-methanediyl bis[dihydrogen (phosphorodithioate)] in which all the hydroxy groups have been converted to their corresponding ethyl esters respectively. Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase ( EC 3.1.1.7).
Chemical ID: MESH:C100038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased activity of NR1I2 protein; ethion binds to and results in increased activity of NR1I2 proteinPMID:21115097 PMID:25028461
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDethion binds to and results in increased activity of NR1I2 proteinPMID:21115097
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