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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:38658
Term: dicrotophos
Definition: An organophosphate insecticide that has formula C8H16NO5P.
Chemical ID: MESH:C000944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Achedecreases activityEXP 6480464CTDdicrotophos results in decreased activity of ACHE proteinPMID:33720374
Achedecreases activityISOACHE (Homo sapiens)6480464CTDdicrotophos metabolite results in decreased activity of ACHE protein; dicrotophos results in decreased activity of ACHE proteinPMID:30625376 PMID:33720374 PMID:8783813
Achemultiple interactionsISOACHE (Homo sapiens)6480464CTDasoxime chloride inhibits the reaction [dicrotophos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [dicrotophos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [dicrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dicrotophos results in decreased activity of ACHE protein]PMID:8783813
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