GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | increases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | 3-methyladenine results in increased expression of IL6 mRNA | PMID:31513885 | Il6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | 3-methyladenine inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL6 mRNA] | PMID:29078374 PMID:31513885 PMID:34051206 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein] | PMID:28867211 PMID:29781141 | | ||||||||||||||||||||||
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