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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349272
Species: Homo sapiens
RGD Object: Gene
Symbol: PON1
Name: paraoxonase 1
Acc ID: CHEBI:38561
Term: fluvastatin
Definition: A racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. An HMG-CoA reductase inhibitor, it is used (often as the corresponding sodium salt) to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia.
Chemical ID: MESH:C065180
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PON1decreases activityISOPon1 (Rattus norvegicus)6480464CTDfluvastatin results in decreased activity of PON1 proteinPMID:14668577
PON1multiple interactionsISOPon1 (Rattus norvegicus)6480464CTDfluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]PMID:14668577
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