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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736447
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:38221
Term: fumonisin B1
Definition: A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol.
Chemical ID: MESH:C056933
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA5increases expressionEXP 6480464CTDfumonisin B1 results in increased expression of HSPA5 mRNA; fumonisin B1 results in increased expression of HSPA5 proteinPMID:31891755
HSPA5multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [fumonisin B1 results in increased expression of HSPA5 protein]; thermozymocidin inhibits the reaction [fumonisin B1 results in increased expression of HSPA5 protein]PMID:31891755
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