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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:38211
Term: potassium bromate
Definition: A bromate salt that has formula BrKO3.
Chemical ID: MESH:C019536
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aaffects expressionISOCdkn1a (Rattus norvegicus)6480464CTDpotassium bromate affects the expression of CDKN1A mRNA; potassium bromate affects the expression of CDKN1A proteinPMID:25015661
Cdkn1aaffects methylationISOCdkn1a (Rattus norvegicus)6480464CTDpotassium bromate affects the methylation of CDKN1A genePMID:25015661
Cdkn1aincreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDpotassium bromate results in increased expression of CDKN1A mRNA; potassium bromate results in increased expression of CDKN1A proteinPMID:20067818 PMID:23588252 PMID:23811332
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDpotassium bromate results in increased expression of CDKN1A mRNA; potassium bromate results in increased expression of CDKN1A proteinPMID:20067818 PMID:30008028 PMID:30559759
Cdkn1amultiple interactionsISOCdkn1a (Rattus norvegicus)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [potassium bromate results in increased expression of CDKN1A protein]; Ascorbic Acid inhibits the reaction [potassium bromate results in increased expression of CDKN1A protein]; Azacitidine inhibits the reaction [potassium bromate results in increased expression of CDKN1A protein]; trichostatin A inhibits the reaction [potassium bromate results in increased expression of CDKN1A protein]PMID:20067818 PMID:25015661
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [potassium bromate results in increased expression of CDKN1A protein]; Ascorbic Acid inhibits the reaction [potassium bromate results in increased expression of CDKN1A protein]PMID:20067818
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