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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732503
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:379896
Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Chemical ID: MESH:D015741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationISOMapk1 (Rattus norvegicus)6480464CTDMetribolone results in increased phosphorylation of MAPK1 proteinPMID:17272394
Mapk1multiple interactionsISOMapk1 (Rattus norvegicus)6480464CTDRTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK1 protein]PMID:17272394
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