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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68978
Species: Homo sapiens
RGD Object: Gene
Symbol: CLU
Name: clusterin
Acc ID: CHEBI:379896
Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Chemical ID: MESH:D015741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CLUdecreases expressionEXP 6480464CTDMetribolone results in decreased expression of CLU mRNA alternative formPMID:17148459
CLUincreases expressionEXP 6480464CTDMetribolone results in increased expression of CLU mRNA; Metribolone results in increased expression of CLU mRNA alternative form; Metribolone results in increased expression of CLU proteinPMID:17010196 PMID:17148459 PMID:17325745
CLUmultiple interactionsEXP 6480464CTDbicalutamide inhibits the reaction [Metribolone results in increased expression of CLU mRNA]; bicalutamide inhibits the reaction [Metribolone results in increased expression of CLU protein]; Metribolone promotes the reaction [AR protein binds to CLU enhancer]PMID:17148459 PMID:17325745
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