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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620111
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncoa6
Name: nuclear receptor coactivator 6
Acc ID: CHEBI:379896
Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Chemical ID: MESH:D015741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa6increases expressionISONCOA6 (Homo sapiens)6480464CTDMetribolone results in increased expression of NCOA6 mRNAPMID:17010196
Ncoa6multiple interactionsISONCOA6 (Homo sapiens)6480464CTD[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA6 protein modified form]PMID:28751236
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