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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3078
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Men1
Name: menin 1
Acc ID: CHEBI:379896
Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Chemical ID: MESH:D015741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7364436480464CTD[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form]

PMID:28751236
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.