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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:37943
Term: colistin
Definition: A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.
Chemical ID: MESH:D003091
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases expressionEXP 6480464CTDColistin results in decreased expression of AKT1 protein modified formPMID:35378205
AKT1decreases phosphorylationEXP 6480464CTDColistin results in decreased phosphorylation of AKT1 proteinPMID:35378205
AKT1decreases expressionISOAkt1 (Mus musculus)6480464CTDColistin results in decreased expression of AKT1 protein modified formPMID:35378205
AKT1decreases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDColistin results in decreased phosphorylation of AKT1 proteinPMID:28465020
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]PMID:28465020
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