Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352582
Species: Homo sapiens
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:37941
Term: clopidogrel
Definition: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.
Chemical ID: MESH:C055162
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6increases response to substanceEXP 6480464CTDIL6 protein results in increased susceptibility to clopidogrelPMID:17537833
IL6multiple interactionsEXP 6480464CTDclopidogrel promotes the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]PMID:24793913
IL6decreases expressionISOIl6 (Mus musculus)6480464CTDclopidogrel results in decreased expression of IL6 mRNAPMID:19155974
IL6multiple interactionsISOIl6 (Mus musculus)6480464CTDclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]PMID:24849676
Go Back to source page   Continue to Ontology report