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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737517
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:37918
Term: fluorescein 5-isothiocyanate
Definition: The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.
Chemical ID: MESH:D016650
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT3increases phosphorylationISOStat3 (Mus musculus)6480464CTDFluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 proteinPMID:27871981
STAT3multiple interactionsISOStat3 (Mus musculus)6480464CTDdiisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]PMID:27871981
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