Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:3766
Term: clozapine
Definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
Chemical ID: MESH:D003024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDClozapine results in decreased expression of BAX proteinPMID:17069804
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDClozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX proteinPMID:16160616
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDCSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]PMID:16160616
Go Back to source page   Continue to Ontology report