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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734157
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c29
Name: cytochrome P450, family 2, subfamily c, polypeptide 29
Acc ID: CHEBI:3764
Term: clotrimazole
Definition: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.
Chemical ID: MESH:D003022
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c29decreases activityISOCYP2C8 (Homo sapiens)6480464CTDClotrimazole results in decreased activity of CYP2C8 proteinPMID:15601807 PMID:33775687
Cyp2c29multiple interactionsISOCyp2c6 (Rattus norvegicus)6480464CTDClotrimazole inhibits the reaction [CYP2C6V1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]PMID:19858067
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