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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62191
Species: Mus musculus
RGD Object: Gene
Symbol: Maoa
Name: monoamine oxidase A
Acc ID: CHEBI:3763
Term: clorgyline
Definition: An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.
Chemical ID: MESH:D003010
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Maoadecreases activityEXP 6480464CTDClorgyline results in decreased activity of MAOA proteinPMID:23009399
Maoamultiple interactionsEXP 6480464CTD[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; [Clorgyline results in decreased activity of MAOA protein] which results in increased susceptibility to MethamphetaminePMID:1905457 PMID:23499958
Maoadecreases activityISOMaoa (Rattus norvegicus)6480464CTDClorgyline results in decreased activity of MAOA proteinPMID:12818349 PMID:16252076
Maoadecreases activityISOMAOA (Homo sapiens)6480464CTDClorgyline results in decreased activity of MAOA proteinPMID:21923181 PMID:27270453
Maoamultiple interactionsISOMaoa (Rattus norvegicus)6480464CTDPhenylpropanolamine inhibits the reaction [Clorgyline results in decreased activity of MAOA protein]PMID:3961266
Maoamultiple interactionsISOMAOA (Homo sapiens)6480464CTDClorgyline inhibits the reaction [MAOA protein results in increased degradation of Serotonin]PMID:30036687
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