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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68334
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S1pr2
Name: sphingosine-1-phosphate receptor 2
Acc ID: CHEBI:37550
Term: sphingosine 1-phosphate
Definition: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Chemical ID: MESH:C060506
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S1pr2increases activityEXP 6480464CTDsphingosine 1-phosphate results in increased activity of S1PR2 protein

PMID:22406263
S1pr2multiple interactionsEXP 6480464CTD[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein] [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein] [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose] [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1

PMID:22406263
S1pr2increases uptakeISORGD:13439376480464CTDsphingosine 1-phosphate results in increased uptake of S1PR2 protein

PMID:26518876
S1pr2multiple interactionsISORGD:13439376480464CTDS1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]

PMID:18612546
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