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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:37550
Term: sphingosine 1-phosphate
Definition: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Chemical ID: MESH:C060506
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionISORGD:13484376480464CTDsphingosine 1-phosphate results in increased expression of MMP9 mRNA sphingosine 1-phosphate results in increased expression of MMP9 protein

PMID:25980589 PMID:26518876
Mmp9multiple interactionsISORGD:13484376480464CTDFingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA] Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein] JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA] JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein] Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA] Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]

PMID:25980589 PMID:26518876
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