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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:37550
Term: sphingosine 1-phosphate
Definition: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Chemical ID: MESH:C060506
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3multiple interactionsEXP 6480464CTD2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form] [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form

PMID:22406263
Mapk3increases phosphorylationISORGD:6195706480464CTDsphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein

PMID:18612546 PMID:26518876
Mapk3multiple interactionsISORGD:6195706480464CTDJTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein] Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein] sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein] U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]

PMID:16365044 PMID:18612546 PMID:22251058 PMID:26518876
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