Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	735868
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	NQO1
Name:	NAD(P)H quinone dehydrogenase 1

Acc ID:	CHEBI:37537
Term:	phorbol 13-acetate 12-myristate
Definition:	A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:	MESH:D013755

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
NQO1	increases expression	EXP		6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of NQO1 mRNA; Tetradecanoylphorbol Acetate results in increased expression of NQO1 protein	PMID:24481452 PMID:24632381
NQO1	multiple interactions	EXP		6480464	CTD	2-tert-butylhydroquinone promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of NQO1 mRNA]; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NQO1 mRNA; Arsenicals promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of NQO1 mRNA]	PMID:16979875 PMID:24632381
NQO1	increases expression	ISO	Nqo1 (Mus musculus)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of NQO1 protein	PMID:24481452
NQO1	multiple interactions	ISO	Nqo1 (Mus musculus)	6480464	CTD	ARNT protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of NQO1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of NQO1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of NQO1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Lead results in increased expression of NQO1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Lead results in increased expression of NQO1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 protein]	PMID:18752316 PMID:24481452

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