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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735727
Species: Homo sapiens
RGD Object: Gene
Symbol: PLAU
Name: plasminogen activator, urokinase
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLAUincreases secretionEXP 6480464CTDTetradecanoylphorbol Acetate results in increased secretion of PLAU proteinPMID:15962302
PLAUmultiple interactionsEXP 6480464CTDarsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of PLAU protein]PMID:15962302
PLAUincreases expressionISOPlau (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased expression of PLAU proteinPMID:9848099
PLAUmultiple interactionsISOPlau (Mus musculus)6480464CTDTAC 101 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PLAU protein]PMID:9848099
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