Gene Chemical Interaction Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	733197
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	TRPV1
Name:	transient receptor potential cation channel subfamily V member 1

Acc ID:	CHEBI:37537
Term:	phorbol 13-acetate 12-myristate
Definition:	A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:	MESH:D013755

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
TRPV1	increases expression	EXP		6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of TRPV1 mRNA	PMID:36847817
TRPV1	multiple interactions	EXP		6480464	CTD	Tetradecanoylphorbol Acetate inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]	PMID:17913835
TRPV1	increases activity	ISO	Trpv1 (Rattus norvegicus)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein	PMID:11140687
TRPV1	increases localization	ISO	Trpv1 (Mus musculus)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased localization of TRPV1 protein	PMID:16319926
TRPV1	multiple interactions	ISO	Trpv1 (Mus musculus)	6480464	CTD	RTKI cpd inhibits the reaction [TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]]; Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the activity of TRPV1 protein; TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]; TRPV1 results in decreased susceptibility to [Capsaicin co-treated with Tetradecanoylphorbol Acetate]; U 0126 inhibits the reaction [TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]]	PMID:19553475 PMID:20660715
TRPV1	multiple interactions	ISO	Trpv1 (Rattus norvegicus)	6480464	CTD	bisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]; Capsaicin promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [resiniferatoxin binds to TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [anandamide results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Lidocaine results in increased activity of TRPV1 protein]	PMID:11140687 PMID:15363968 PMID:18172555 PMID:19553475

Go Back to source page

Continue to Ontology report