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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733129
Species: Mus musculus
RGD Object: Gene
Symbol: Vim
Name: vimentin
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vimincreases expressionEXP 6480464CTDTetradecanoylphorbol Acetate results in increased expression of VIM proteinPMID:28108223
Vimmultiple interactionsEXP 6480464CTD[sodium arsenite results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]] which results in increased expression of VIM protein; morusin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]PMID:28108223 PMID:35364107
Vimincreases expressionISOVIM (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of VIM proteinPMID:25656647
Vimmultiple interactionsISOVIM (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]; [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VIM mRNA]; [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VIM mRNA; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]PMID:15477007 PMID:25656647
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