Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	730886
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	CREB1
Name:	cAMP responsive element binding protein 1

Acc ID:	CHEBI:37537
Term:	phorbol 13-acetate 12-myristate
Definition:	A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:	MESH:D013755

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
CREB1	increases activity	EXP		6480464	CTD	Tetradecanoylphorbol Acetate results in increased activity of CREB1 protein	PMID:18791200
CREB1	increases phosphorylation	EXP		6480464	CTD	Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein	PMID:10601319 PMID:20032081 PMID:31068361
CREB1	multiple interactions	EXP		6480464	CTD	GW 1929 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]; Rosiglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]	PMID:20032081
CREB1	increases phosphorylation	ISO	Creb1 (Mus musculus)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein	PMID:19282384 PMID:21047949
CREB1	multiple interactions	ISO	Creb1 (Mus musculus)	6480464	CTD	[Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]] promotes the reaction [CREBBP protein binds to STAR promoter]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]; CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA]; CREBBP protein promotes the reaction [CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; PRKD1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; PRKD1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of CREB1 protein modified form]; Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased phosphorylation of CREB1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]	PMID:19282384 PMID:21047949 PMID:35608139

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