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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730855
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD1
Name: superoxide dismutase 1
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD1decreases expressionEXP 6480464CTDTetradecanoylphorbol Acetate results in decreased expression of SOD1 proteinPMID:24073338
SOD1increases expressionEXP 6480464CTDTetradecanoylphorbol Acetate results in increased expression of SOD1 proteinPMID:20831825
SOD1multiple interactionsEXP 6480464CTDTetradecanoylphorbol Acetate promotes the reaction [Glucose deficiency results in decreased expression of and results in increased degradation of SOD1 protein]PMID:17309078
SOD1decreases expressionISOSod1 (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in decreased expression of SOD1 proteinPMID:20045496
SOD1multiple interactionsISOSod1 (Mus musculus)6480464CTD[decursin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SOD1 proteinPMID:31351099
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