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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730822
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases activityISOMMP2 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased activity of MMP2 proteinPMID:10455257 PMID:20152819 PMID:20599481
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA; Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein; Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein modified formPMID:10569804 PMID:17498959 PMID:18155510 PMID:19375915 PMID:20152819 PMID:20590612 PMID:20599481 PMID:31545954
Mmp2increases secretionISOMMP2 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased secretion of MMP2 proteinPMID:15962302
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; 3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; 3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]; Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP2 protein]; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; artenimol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; Beclomethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]; Glucosamine analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein]; Glucosamine analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; Glucosamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; Glucosamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]; Hydroxamic Acids inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]; Hydroxamic Acids inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP2 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]; oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein; Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP2 protein; tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein modified form]; Troglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; Vanadates inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]; Vorinostat inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP2 protein]PMID:10455257 PMID:10569804 PMID:15962302 PMID:17498959 PMID:18155510 PMID:19375915 PMID:20152819 PMID:20590612 PMID:20599481 PMID:27163855 PMID:31545954
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