Gene Chemical Interaction Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	69659
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	ICAM1
Name:	intercellular adhesion molecule 1

Acc ID:	CHEBI:37537
Term:	phorbol 13-acetate 12-myristate
Definition:	A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:	MESH:D013755

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
ICAM1	increases expression	EXP		6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of ICAM1 mRNA; Tetradecanoylphorbol Acetate results in increased expression of ICAM1 protein	PMID:10484327 PMID:11164475
ICAM1	multiple interactions	EXP		6480464	CTD	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]]; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ICAM1 protein]; [Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ICAM1 protein; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ICAM1 mRNA]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ICAM1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]	PMID:10484327 PMID:11164475 PMID:20920494 PMID:30218697
ICAM1	increases expression	ISO	Icam1 (Mus musculus)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of ICAM1 protein	PMID:31351099
ICAM1	multiple interactions	ISO	Icam1 (Mus musculus)	6480464	CTD	decursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ICAM1 protein]	PMID:31351099

Go Back to source page

Continue to Ontology report