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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69169
Species: Mus musculus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargincreases activityISOPPARG (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased activity of PPARG proteinPMID:15707588
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of PPARG mRNA; Tetradecanoylphorbol Acetate results in increased expression of PPARG proteinPMID:12044893 PMID:16945329
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD[2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; [2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of troglitazone]; [Tetradecanoylphorbol Acetate co-treated with Calcium Ionophores] affects the expression of PPARG mRNA; [Tetradecanoylphorbol Acetate results in increased expression of PPARG] which affects the susceptibility to troglitazone; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; MAP2K1 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]; Reactive Oxygen Species affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]PMID:16945329 PMID:21511917
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