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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619554
Species: Homo sapiens
RGD Object: Gene
Symbol: CD36
Name: CD36 molecule (CD36 blood group)
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CD36decreases expressionEXP 6480464CTDTetradecanoylphorbol Acetate results in decreased expression of CD36 mRNAPMID:12664607
CD36increases expressionEXP 6480464CTDTetradecanoylphorbol Acetate results in increased expression of CD36 mRNA; Tetradecanoylphorbol Acetate results in increased expression of CD36 proteinPMID:16484594 PMID:21315065 PMID:23386263 PMID:30218697 PMID:32649966 PMID:34506768
CD36multiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [[Rosiglitazone co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein]; [15-deoxyprostaglandin J2 co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein; [2-acetyltributylcitrate co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 mRNA; [Rosiglitazone co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein; [titanium dioxide co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CD36 protein; [Zinc Oxide analog co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein; Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; bisdemethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]; demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]; Dibutyl Phthalate inhibits the reaction [[Rosiglitazone co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein]; Dibutyl Phthalate promotes the reaction [[15-deoxyprostaglandin J2 co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD36 protein]; Dibutyl Phthalate promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]; tamibarotene promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]]PMID:16484594 PMID:21315065 PMID:23386263 PMID:24746987 PMID:30218697 PMID:37055963
CD36increases expressionISOCd36 (Rattus norvegicus)6480464CTDTetradecanoylphorbol Acetate results in increased expression of CD36 mRNA; Tetradecanoylphorbol Acetate results in increased expression of CD36 proteinPMID:16407258
CD36increases expressionISOCd36 (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased expression of CD36 mRNAPMID:16484594
CD36multiple interactionsISOCd36 (Mus musculus)6480464CTDtamibarotene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]PMID:16484594
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