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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in decreased expression of ESR1 mRNA; Tetradecanoylphorbol Acetate results in decreased expression of ESR1 proteinPMID:10633228 PMID:9706865
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of ESR1 mRNAPMID:20559769
Esr1multiple interactionsISOEsr1 (Mus musculus)6480464CTD[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ESR1 mRNA; [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ESR1 protein; Tetradecanoylphorbol Acetate promotes the reaction [Estradiol results in increased expression of ESR1 protein]PMID:16368122 PMID:19340542
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDPlant Extracts inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]; Plant Extracts promotes the reaction [Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]]; Tamoxifen inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ESR1 mRNA]PMID:20559769
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