Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2199
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Bcl2
Name:	BCL2, apoptosis regulator

Acc ID:	CHEBI:37537
Term:	phorbol 13-acetate 12-myristate
Definition:	A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID:	MESH:D013755

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Bcl2	multiple interactions	EXP		6480464	CTD	Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BCL2 protein]	PMID:36925031
Bcl2	decreases expression	ISO	BCL2 (Homo sapiens)	6480464	CTD	Tetradecanoylphorbol Acetate results in decreased expression of BCL2 protein	PMID:11139146
Bcl2	increases expression	ISO	Bcl2 (Mus musculus)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein	PMID:19161993
Bcl2	increases expression	ISO	BCL2 (Homo sapiens)	6480464	CTD	Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein	PMID:24073338 PMID:9295281
Bcl2	multiple interactions	ISO	Bcl2 (Mus musculus)	6480464	CTD	[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BCL2 protein; [Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of BCL2 protein; beta-elemene inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BCL2 protein]; geraniol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of BCL2 protein]; perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Quercetin results in decreased expression of BCL2 protein]	PMID:15538571 PMID:19161993 PMID:22760862 PMID:32662567
Bcl2	multiple interactions	ISO	BCL2 (Homo sapiens)	6480464	CTD	[Graphite analog co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BCL2 protein; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of BCL2 mRNA; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [myricetin results in decreased expression of BCL2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in decreased expression of BCL2 protein]	PMID:15748703 PMID:16979875 PMID:19631781 PMID:25446327 PMID:9295281

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