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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding acetate and myristate esters.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDTetradecanoylphorbol Acetate inhibits the reaction [EGF protein binds to EGFR protein]

PMID:6309801
increases expressionISORGD:7368326480464CTDTetradecanoylphorbol Acetate results in increased expression of EGF protein

PMID:19447859
multiple interactionsISORGD:25426480464CTDbisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein], Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein], Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein], TAPI-2 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein], Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein, Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]]

PMID:12947092
multiple interactionsISORGD:7368326480464CTDpterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGF protein]

PMID:19447859
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.