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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595919
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a62
Name: cytochrome P450, family 3, subfamily a, polypeptide 62
Acc ID: CHEBI:3720
Term: cisapride
Definition: The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.
Chemical ID: MESH:D020117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
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