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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:3699
Term: cimetidine
Definition: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Chemical ID: MESH:D002927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDCimetidine results in decreased activity of CYP2D6 protein

PMID:17651725
multiple interactionsEXP 6480464CTDCimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]

PMID:17651725
decreases activityISORGD:7362176480464CTDCimetidine results in decreased activity of CYP2D6 protein

PMID:19909766
multiple interactionsISORGD:7362176480464CTDstyrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein]

PMID:19909766
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.