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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620324
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dpep1
Name: dipeptidase 1
Acc ID: CHEBI:3697
Term: cilastatin
Definition: The thioether resulting from the formal oxidative coupling of the thiol group of L-cysteine with the 7-position of (2Z)-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin is therefore administered (as the sodium salt) with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to inactive and potentially nephrotoxic products. Cilastatin also acts as a leukotriene D4 dipeptidase inhibitor, preventing the metabolism of leukotriene D4 to leukotriene E4.
Chemical ID: MESH:D015377
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dpep1decreases activityISORGD:13505376480464CTDCilastatin results in decreased activity of DPEP1 proteinPMID:30664745
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