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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:36904
Term: elemental selenium
Definition: null
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx4decreases abundanceEXP 6480464CTDGPX4 gene mutant form results in decreased abundance of SeleniumPMID:16246897
Gpx4decreases expressionEXP 6480464CTDSelenium deficiency results in decreased expression of GPX4 proteinPMID:34970773
Gpx4multiple interactionsEXP 6480464CTDSelenomethionine inhibits the reaction [Selenium deficiency results in decreased expression of GPX4 protein]; Sodium Selenite inhibits the reaction [Selenium deficiency results in decreased expression of GPX4 protein]PMID:34970773
Gpx4affects activityISOGpx4 (Rattus norvegicus)6480464CTDSelenium affects the activity of GPX4 proteinPMID:19106321
Gpx4decreases activityISOGpx4 (Rattus norvegicus)6480464CTDSelenium deficiency results in decreased activity of GPX4 proteinPMID:12031252
Gpx4decreases expressionISOGpx4 (Rattus norvegicus)6480464CTDSelenium deficiency results in decreased expression of GPX4 mRNAPMID:12031252 PMID:15670848 PMID:15792362
Gpx4decreases expressionISOGPX4 (Homo sapiens)6480464CTDSelenium deficiency results in decreased expression of GPX4 mRNAPMID:15670848
Gpx4increases activityISOGpx4 (Rattus norvegicus)6480464CTDSelenium results in increased activity of GPX4 proteinPMID:19022953
Gpx4increases activityISOGPX4 (Homo sapiens)6480464CTDSelenium analog results in increased activity of GPX4 proteinPMID:11673642
Gpx4increases expressionISOGpx4 (Rattus norvegicus)6480464CTDSelenium results in increased expression of GPX4 mRNAPMID:15792362 PMID:19022953
Gpx4increases expressionISOGPX4 (Homo sapiens)6480464CTDSelenium results in increased expression of GPX4 mRNA; Selenium results in increased expression of GPX4 proteinPMID:17052796 PMID:19244175
Gpx4multiple interactionsISOGpx4 (Rattus norvegicus)6480464CTD[2-hydroxy-4-methylselenobutanoic acid results in increased abundance of Selenium] which results in increased expression of GPX4 proteinPMID:34116104
Gpx4multiple interactionsISOGPX4 (Homo sapiens)6480464CTDSelenium results in increased expression of and results in increased activity of GPX4 proteinPMID:17150329
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